An image of a woman playing basketball.

An image of a woman playing basketball.

#1 South Carolina vs. #16 Southern Prediction, Odds, & How to Watch: March Madness® 2026

#1 South Carolina and #16 Southern meet at Colonial Life Arena for a high-stakes First Round matchup. Here are details, our prediction, and how to watch with Sling TV.

The overall No. 1 seed South Carolina Gamecocks (31-3) open their March Madness® run at home following an SEC Championship game loss to Texas. They host the Southern Jaguars (20-13), who advanced to the Round of 64 after defeating Samford by 12 points in the First Four®. South Carolina enters the tournament as a dominant force, leading the nation in points per possession (1.222) and seeking their fourth national title under head coach Dawn Staley. The Jaguars arrive in Columbia on a hot streak, having won eight of their last 10 games.

To watch the Gamecocks vs. Jaguars First Round game with Sling, use the link below for a monthly subscription to Sling Orange + Blue with ABC in designated markets.

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Game Detail
Information
Matchup
#1 South Carolina vs. #16 Southern
Date/Time
Saturday, March 21, 2026 at 1:00 PM ET
Location
Colonial Life Arena, Columbia, SC
Channel
ABC
Watch With Sling
Monthly subscription to Sling Blue with ABC in designated markets
Opening Spread
South Carolina -52.5 (O/U 130.5)

South Carolina Gamecocks Analysis

Southern Jaguars Analysis

Key Matchup & Advanced Analytics

Final Prediction & Betting Pick

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